Review the key concepts, formulae, and examples before starting your quiz.
🔑Concepts
The respiratory balance sheet is a theoretical calculation of the net gain of for every molecule of glucose oxidized during aerobic respiration.
It is based on certain assumptions: the metabolic pathway is sequential (Glycolysis TCA Cycle ETS), synthesized in glycolysis is transferred into the mitochondria, and no intermediates of the pathway are utilized to synthesize any other compound.
In the Electron Transport System (ETS), the oxidation of one molecule of gives molecules of , and one molecule of gives molecules of .
During Glycolysis, there is a net gain of (Direct) and .
In the Link Reaction (oxidative decarboxylation of Pyruvate), molecules of are produced per glucose molecule.
In the Krebs Cycle (TCA), per glucose molecule (two turns), there is a gain of (equivalent to ), , and .
The total theoretical yield of per glucose molecule is , though in most eukaryotic cells, the net gain is due to the cost of transporting into the mitochondria.
📐Formulae
💡Examples
Problem 1:
Calculate the total number of molecules produced specifically through substrate-level phosphorylation (SLP) during the complete oxidation of one molecule of glucose.
Solution:
The total is .
Explanation:
Substrate-level phosphorylation occurs in two stages: are produced during Glycolysis and (which is equivalent to ) are produced during the Krebs cycle (one per turn, and there are two turns per glucose). Thus,
Problem 2:
How many molecules are generated from the and produced during only the Krebs Cycle for one molecule of Glucose?
Solution:
The total is .
Explanation:
In the Krebs cycle, one glucose molecule results in and . Using the conversion factors: (from ) and (from ). Total is .