krit.club logo

Human Health and Diseases - Allergies and Auto-immunity

Grade 12CBSEBiology

Review the key concepts, formulae, and examples before starting your quiz.

🔑Concepts

•

Allergy is defined as the exaggerated or hypersensitive response of the immune system to certain antigens present in the environment.

•

Allergens are the substances that cause an allergic response, such as pollen, dust mites, dander, etc.

•

The antibodies produced during an allergic reaction are specifically of the IgEIgE type.

•

Allergic reactions are triggered by the release of chemicals like histaminehistamine and serotoninserotonin from mast cellsmast\ cells in the body.

•

Common symptoms of allergy include sneezing, watery eyes, running nose, and difficulty in breathing (as seen in asthma).

•

Treatment for allergies involves the administration of drugs like anti−histaminesanti-histamines, adrenalineadrenaline, and steroidssteroids which quickly reduce symptoms.

•

Auto-immunity is a condition where the body's immune system loses the ability to distinguish 'self' cells from 'non-self' cells and starts attacking its own body cells.

•

The exact cause of auto-immunity is often unknown, though genetic factors and environmental triggers play a significant role.

•

A classic example of an auto-immune disease is Rheumatoid arthritisRheumatoid\ arthritis, where the immune system attacks the joints.

📐Formulae

Allergen+IgE→Mast Cell Activation→Release of Histamine/Serotonin\text{Allergen} + IgE \rightarrow \text{Mast Cell Activation} \rightarrow \text{Release of Histamine/Serotonin}

Treatment=Anti-histamines+Adrenaline+Steroids\text{Treatment} = \text{Anti-histamines} + \text{Adrenaline} + \text{Steroids}

Antibody Structure=H2L2\text{Antibody Structure} = H_2L_2

💡Examples

Problem 1:

A 10-year-old child living in a metro city suffers from repeated bouts of wheezing and breathlessness whenever exposed to dust. Identify the condition and the likely cause based on modern lifestyle.

Solution:

The condition is AsthmaAsthma (a form of allergy).

Explanation:

Modern lifestyle in cities involves a protected environment with less exposure to natural antigens early in life. This results in hypersensitivity to allergens like dust, leading to IgEIgE mediated inflammatory responses in the airways.

Problem 2:

Explain why Rheumatoid arthritisRheumatoid\ arthritis is categorized as an auto-immune disease.

Solution:

It involves the immune system attacking self-antigens in the joints.

Explanation:

In Rheumatoid arthritisRheumatoid\ arthritis, the body's immune system fails to recognize the synovial membrane and other joint tissues as 'self' and attacks them, leading to chronic inflammation and joint deformity.