Inheritance
Each subtopic includes About section, revision page link, 10 preview questions, and practice CTAs.
Chromosomes, genes and proteins
SubtopicChromosomes, genes and proteins under Inheritance for Grade 12 IGCSE.
Preview questions (no answers)
- 1.
What holds the code for a single protein?
A.The whole chromosome
B.A single gene
C.The entire genome
D.A single nucleotide
- 2.
Which term describes an allele that is only expressed if two copies are present?
A.Dominant
B.Recessive
C.Heterozygous
D.Co-dominant
- 3.
Which of the following is a primary role of chromosomes?
A.Energy production
B.Carrying genetic information
C.Digestion of nutrients
D.Transporting oxygen
- 4.
How many pairs of chromosomes are found in a normal human body cell?
A.23
B.46
C.44
D.2
- 5.
Which of the following molecules contains a deoxyribose sugar?
A.mRNA
B.tRNA
C.DNA
D.rRNA
- 6.
What does it mean if an individual is described as being 'homozygous' for a particular gene?
A.They have two different alleles for that gene
B.They have two identical alleles for that gene
C.They only have one copy of that gene
D.The gene is located on the X chromosome
- 7.
If a template DNA strand has the sequence , what is the sequence of the corresponding mRNA codon?
A.B.C.D. - 8.
A specific gene codes for a functional protein containing 60 amino acids. A point mutation occurs, changing the mRNA codon from to . During the translation process, amino acids are linked via condensation reactions. Based on the diagram and your knowledge of protein synthesis, how many fewer water molecules are released during the synthesis of the polypeptide from the mutated mRNA compared to the original mRNA?
A.19
B.20
C.21
D.40
- 9.
A researcher discovers a mutation in a gene that prevents the mRNA from binding to the ribosome. This would directly stop which process?
A.Transcription
B.Translation
C.DNA Replication
D.Mitosis
- 10.
What is the main reason that the two strands of DNA can be separated relatively easily during processes like replication and transcription?
A.The phosphodiester bonds are very weak.
B.The two strands are held together by relatively weak hydrogen bonds.
C.The sugar-phosphate backbone is highly flexible.
D.Enzymes are not required to break the bonds between the strands.
Download the worksheet for Inheritance - Chromosomes, genes and proteins to practice offline. It includes additional chapter-level practice questions.
Monohybrid inheritance
SubtopicMonohybrid inheritance under Inheritance for Grade 12 IGCSE.
Preview questions (no answers)
- 1.
The location of a specific gene on a chromosome is known as its:
A.Locus
B.Allele
C.Genotype
D.Phenotype
- 2.
In a cross between and , what percentage of the offspring will have the genotype ?
A.B.C.D. - 3.
Which allele is always expressed in the phenotype of a heterozygous individual?
A.Recessive
B.Dominant
C.Both alleles
D.Neither allele
- 4.
If two plants from a cross are bred together, the resulting generation is called:
A.The generation
B.The generation
C.The generation
D.The generation
- 5.
In the following cross, what proportion of the offspring are expected to be heterozygous?
A.25%
B.50%
C.75%
D.100%
- 6.
In humans, brown eyes () are generally dominant over blue eyes (). If two brown-eyed parents have a blue-eyed child, what is the probability that their next child will also have blue eyes?
A.0
B.0.25
C.0.50
D.0.75
- 7.
When Mendel crossed pure-breeding tall plants with pure-breeding short plants, why were no short plants seen in the generation?
A.The short allele was lost during fertilization
B.The tall allele is dominant over the short allele
C.The short plants failed to produce pollen
D.The generation only underwent mitosis
- 8.
A researcher is studying a trait in a population where 16% of individuals show the recessive phenotype. If the population is in equilibrium, what is the estimated frequency of the heterozygous genotype?
A.0.16
B.0.32
C.0.48
D.0.60
- 9.
In a cross between two individuals that are heterozygous for a recessive lethal allele (meaning individuals die before birth), what is the expected proportion of the surviving offspring that will be carriers of the lethal allele?
A.1/4
B.1/2
C.2/3
D.3/4
- 10.
An organism has the genotype . During meiosis, the alleles and separate. What is the name of this principle discovered by Mendel?
A.Law of Independent Assortment
B.Law of Segregation
C.Law of Dominance
D.Law of Linkage
Download the worksheet for Inheritance - Monohybrid inheritance to practice offline. It includes additional chapter-level practice questions.
Mitosis and Meiosis
SubtopicMitosis and Meiosis under Inheritance for Grade 12 IGCSE.
Preview questions (no answers)
- 1.
Which of the following is produced via mitosis?
A.Sperm cells
B.Egg cells
C.New skin cells
D.Pollen grains
- 2.
Which phase of mitosis involves chromosomes becoming shorter and thicker?
A.Prophase
B.Metaphase
C.Anaphase
D.Telophase
- 3.
A fruit fly has 8 chromosomes in its body cells. How many chromosomes are in its gametes?
A.8
B.16
C.4
D.2
- 4.
Which process results in the formation of a zygote?
A.Meiosis
B.Mitosis
C.Fusion of gametes
D.Cytokinesis
- 5.
Which of the following occurs during the 'M' phase of the cell cycle?
A.DNA replication
B.Cell growth and protein synthesis
C.Nuclear division and cytokinesis
D.Formation of the nuclear envelope after DNA synthesis
- 6.
At the end of Meiosis II, each of the four daughter cells contains:
A.The same number of chromosomes as the parent cell.
B.Double the amount of DNA as the parent cell.
C.One chromosome from each homologous pair.
D.Two identical copies of each chromosome.
- 7.
What is the primary evolutionary advantage of sexual reproduction compared to asexual reproduction?
A.It requires less energy to find a mate.
B.It produces a larger number of offspring in a shorter time.
C.It generates genetic variation, allowing populations to adapt to changing environments.
D.It ensures that harmful mutations are passed on to all offspring.
- 8.
Given a species with , if a nondisjunction event occurs for all chromosomes during Meiosis I, and the resulting gametes are fertilized by normal haploid gametes, what will be the ploidy of the offspring?
A.Triploid (3n)
B.Tetraploid (4n)
C.Monosomic (2n-1)
D.Trisomic (2n+1)
- 9.
Which of the following characterizes 'Anaphase B' of mitosis?
A.The elongation of the whole cell as polar microtubules slide past each other.
B.The shortening of kinetochore microtubules to pull chromosomes to the poles.
C.The reformation of the nuclear envelope around separated chromatids.
D.The attachment of spindle fibers to the centromeric region.
- 10.
In a cell undergoing meiosis, if crossing over happens between sister chromatids instead of non-sister chromatids, what is the genetic consequence?
A.There is no change in the genetic combination of the resulting gametes.
B.The gametes will be aneuploid.
C.The gametes will have double the amount of DNA.
D.The offspring will show increased variation.
Download the worksheet for Inheritance - Mitosis and Meiosis to practice offline. It includes additional chapter-level practice questions.