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Chemical Coordination and Integration - Hormones of heart, kidney and gastrointestinal tract

Grade 11CBSEBiology

Review the key concepts, formulae, and examples before starting your quiz.

🔑Concepts

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Hormones of the Heart: The atrial wall of our heart secretes a very important peptide hormone called Atrial Natriuretic Factor (ANFANF). When blood pressure increases, ANFANF is secreted which causes dilation of the blood vessels. This results in the reduction of blood pressure.

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Hormones of the Kidney: The Juxtaglomerular (JGJG) cells of the kidney produce a peptide hormone called Erythropoietin. This hormone stimulates Erythropoiesis, which is the process of formation of Red Blood Cells (RBCsRBCs).

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Hormones of the Gastrointestinal (GI) Tract: Endocrine cells present in different parts of the GI tract secrete four major peptide hormones: Gastrin, Secretin, Cholecystokinin (CCKCCK), and Gastric Inhibitory Peptide (GIPGIP).

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Gastrin: It acts on the gastric glands and stimulates the secretion of hydrochloric acid (HClHCl) and pepsinogen.

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Secretin: It acts on the exocrine pancreas and stimulates the secretion of water and bicarbonate ions (HCO3−HCO_3^-).

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Cholecystokinin (CCKCCK): It acts on both the pancreas and the gallbladder, stimulating the secretion of pancreatic enzymes and bile juice, respectively.

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Gastric Inhibitory Peptide (GIPGIP): This hormone inhibits gastric secretion and motility.

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Growth Factors: Several other non-endocrine tissues secrete hormones called growth factors, which are essential for the normal growth of tissues and their repairing/regeneration.

📐Formulae

High Blood Pressure→Atrial WallANF  ⟹  Vasodilation  ⟹  ↓Blood Pressure\text{High Blood Pressure} \xrightarrow{\text{Atrial Wall}} ANF \implies \text{Vasodilation} \implies \downarrow \text{Blood Pressure}

Low O2 levels→JG CellsErythropoietin  ⟹  Erythropoiesis (RBC Production)\text{Low } O_2 \text{ levels} \xrightarrow{\text{JG Cells}} \text{Erythropoietin} \implies \text{Erythropoiesis (RBC Production)}

Secretin→Exocrine PancreasH2O+HCO3−\text{Secretin} \xrightarrow{\text{Exocrine Pancreas}} H_2O + HCO_3^-

CCK→GallbladderBile Release\text{CCK} \xrightarrow{\text{Gallbladder}} \text{Bile Release}

💡Examples

Problem 1:

A patient has a significantly low Red Blood Cell count. Which hormone produced by a non-endocrine organ might be deficient, and which cells are responsible for its production?

Solution:

The hormone is Erythropoietin, and it is produced by the Juxtaglomerular (JGJG) cells of the kidney.

Explanation:

Erythropoietin is essential for erythropoiesis. If the JGJG cells of the kidney fail to produce sufficient levels of this hormone, the bone marrow is not adequately stimulated to produce RBCsRBCs.

Problem 2:

Explain the antagonistic relationship between the Renin-Angiotensin mechanism and ANFANF regarding blood pressure.

Solution:

Renin-Angiotensin increases blood pressure via vasoconstriction, while ANFANF decreases blood pressure via vasodilation.

Explanation:

When blood pressure is high, the heart releases ANFANF to cause vasodilation. Conversely, when blood pressure is low, the kidney releases Renin to eventually produce Angiotensin II, which is a powerful vasoconstrictor. Thus, ANFANF acts as a check on the Renin-Angiotensin mechanism.