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Health and Hygiene - Concept of Allergy

Grade 7ICSE

Review the key concepts, formulae, and examples before starting your quiz.

🔑Concepts

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An allergy is an exaggerated or hypersensitive response of the immune system to certain substances in the environment that are normally harmless to most people.

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The substances that trigger an allergic reaction are called allergens. Examples include pollen, dust mites, mold spores, and certain proteins in food like milkmilk or peanutspeanuts.

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When an allergen enters the body, the immune system produces a specific class of antibodies known as IgEIgE (Immunoglobulin E).

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These IgEIgE antibodies bind to specialized cells called mast cells. Upon subsequent exposure to the allergen, these cells release a chemical called histamine (C5H9N3C_{5}H_{9}N_{3}), which causes symptoms like inflammation, sneezing, and itching.

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Entry routes for allergens include Inhalation (e.g., pollenpollen), Ingestion (e.g., nutsnuts), Injection (e.g., bee venombee\ venom), and Contact (e.g., latexlatex or cosmeticscosmetics).

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A severe, life-threatening allergic reaction is known as anaphylaxis, which requires immediate medical attention.

📐Formulae

Allergen+IgE→BindingMast Cell ActivationAllergen + IgE \xrightarrow{Binding} Mast\ Cell\ Activation

Mast Cell→DegranulationHistamine Release→Allergic SymptomsMast\ Cell \xrightarrow{Degranulation} Histamine\ Release \rightarrow Allergic\ Symptoms

C5H9N3 (Chemical formula for Histamine)C_{5}H_{9}N_{3} \text{ (Chemical formula for Histamine)}

💡Examples

Problem 1:

During the spring season, a student experiences continuous sneezing, watery eyes, and a runny nose. Identify the likely allergen and the biological mediator causing these symptoms.

Solution:

The likely allergen is pollenpollen, and the biological mediator is histaminehistamine.

Explanation:

In spring, flowering plants release pollenpollen grains into the air. When inhaled by a sensitive individual, the immune system identifies them as threats and releases histaminehistamine from mast cells, leading to the symptoms of hay fever.

Problem 2:

Explain why a person might react to a bee sting with sudden swelling and redness using scientific terminology.

Solution:

The reaction is caused by venomvenom acting as an allergen, triggering IgEIgE antibodies and histaminehistamine release.

Explanation:

Bee venom is injected into the skin. The body’s immune system produces IgEIgE specific to the venom proteins. This triggers a localized inflammatory response where histaminehistamine increases the permeability of blood vessels, causing swellingswelling and rednessredness at the site of the injectioninjection.