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Health and Hygiene - Concept of Allergy

Grade 7ICSE

Review the key concepts, formulae, and examples before starting your quiz.

🔑Concepts

An allergy is an exaggerated or hypersensitive response of the immune system to certain substances in the environment that are normally harmless to most people.

The substances that trigger an allergic reaction are called allergens. Examples include pollen, dust mites, mold spores, and certain proteins in food like milkmilk or peanutspeanuts.

When an allergen enters the body, the immune system produces a specific class of antibodies known as IgEIgE (Immunoglobulin E).

These IgEIgE antibodies bind to specialized cells called mast cells. Upon subsequent exposure to the allergen, these cells release a chemical called histamine (C5H9N3C_{5}H_{9}N_{3}), which causes symptoms like inflammation, sneezing, and itching.

Entry routes for allergens include Inhalation (e.g., pollenpollen), Ingestion (e.g., nutsnuts), Injection (e.g., bee venombee\ venom), and Contact (e.g., latexlatex or cosmeticscosmetics).

A severe, life-threatening allergic reaction is known as anaphylaxis, which requires immediate medical attention.

📐Formulae

Allergen+IgEBindingMast Cell ActivationAllergen + IgE \xrightarrow{Binding} Mast\ Cell\ Activation

Mast CellDegranulationHistamine ReleaseAllergic SymptomsMast\ Cell \xrightarrow{Degranulation} Histamine\ Release \rightarrow Allergic\ Symptoms

C5H9N3 (Chemical formula for Histamine)C_{5}H_{9}N_{3} \text{ (Chemical formula for Histamine)}

💡Examples

Problem 1:

During the spring season, a student experiences continuous sneezing, watery eyes, and a runny nose. Identify the likely allergen and the biological mediator causing these symptoms.

Solution:

The likely allergen is pollenpollen, and the biological mediator is histaminehistamine.

Explanation:

In spring, flowering plants release pollenpollen grains into the air. When inhaled by a sensitive individual, the immune system identifies them as threats and releases histaminehistamine from mast cells, leading to the symptoms of hay fever.

Problem 2:

Explain why a person might react to a bee sting with sudden swelling and redness using scientific terminology.

Solution:

The reaction is caused by venomvenom acting as an allergen, triggering IgEIgE antibodies and histaminehistamine release.

Explanation:

Bee venom is injected into the skin. The body’s immune system produces IgEIgE specific to the venom proteins. This triggers a localized inflammatory response where histaminehistamine increases the permeability of blood vessels, causing swellingswelling and rednessredness at the site of the injectioninjection.