Biomolecules
Each subtopic includes About section, revision page link, 10 preview questions, and practice CTAs.
Carbohydrates: Classification and functions
SubtopicCarbohydrates: Classification and functions under Biomolecules for Grade 12 ICSE.
Preview questions (no answers)
- 1.
On hydrolysis, Lactose gives a mixture of:
A.Glucose and Fructose
B.Glucose and Glucose
C.Glucose and Galactose
D.Fructose and Galactose
- 2.
Which of the following carbohydrates is classified as an aldopentose?
A.Glucose
B.Ribose
C.Fructose
D.Glyceraldehyde
- 3.
The total number of chiral carbon atoms in the open-chain structure of Glucose is:
A.2
B.3
C.4
D.5
- 4.
Which sugar is found in the mammary glands of lactating animals?
A.Sucrose
B.Lactose
C.Maltose
D.Fructose
- 5.
Based on the physical and chemical classification of carbohydrates shown in the flowchart below, which pair of compounds correctly represents an example for category 'X' and category 'Y' respectively?
A.X: Glucose; Y: Glycogen
B.X: Sucrose; Y: Cellulose
C.X: Starch; Y: Maltose
D.X: Fructose; Y: Amylose
- 6.
Which carbon atom of glucose is called the anomeric carbon?
A.B.C.D. - 7.
When glucose is treated with in the presence of dry gas, it forms methyl glucoside. This indicates the presence of:
A.An open chain aldehyde
B.A hemiacetal group
C.A primary alcohol
D.Five free hydroxyl groups
- 8.
In the reaction of glucose with excess acetic anhydride, the change in molecular mass of the glucose molecule is:
A.42 amu
B.180 amu
C.210 amu
D.260 amu
- 9.
Which of the following pairs represent C-4 epimers?
A.Glucose and Mannose
B.Glucose and Galactose
C.Glucose and Fructose
D.Galactose and Mannose
- 10.
The iodine test for starch produces a blue-black color because:
A.Iodine reacts chemically to form a covalent bond with glucose
B.Iodine molecules are trapped inside the helical structure of amylose
C.Starch is oxidized by iodine to form a colored complex
D.Amylopectin branches trap iodine at the -linkage points
Download the worksheet for Biomolecules - Carbohydrates: Classification and functions to practice offline. It includes additional chapter-level practice questions.
Monosaccharides (Glucose and Fructose)
SubtopicMonosaccharides (Glucose and Fructose) under Biomolecules for Grade 12 ICSE.
Preview questions (no answers)
- 1.
In the cyclic structure of glucose, how many chiral centers are present?
A.4
B.5
C.6
D.3
- 2.
Which of the following products is formed when D-fructose is reduced with sodium amalgam and water?
A.Only Sorbitol
B.Only Mannitol
C.A mixture of Sorbitol and Mannitol
D.Gluconic acid
- 3.
The specific rotation of a freshly prepared solution of -D-glucose changes from to a constant value of . This phenomenon is:
A.Inversion
B.Epimerization
C.Mutarotation
D.Optical activity
- 4.
Which property is shared by both glucose and fructose regarding their behavior with Fehling's solution?
A.Neither is a reducing sugar.
B.Both are reducing sugars.
C.Only glucose is a reducing sugar.
D.Only fructose is a reducing sugar.
- 5.
Which of the following best describes the optical activity of D-Fructose?
A.Dextrorotatory
B.Levorotatory
C.Racemic
D.Optically inactive
- 6.
Which of the following hydroxyl groups in Glucose is the most reactive toward etherification with methanol/HCl?
A.C-2 OH
B.C-3 OH
C.C-6 OH
D.C-1 OH
- 7.
Kiliani-Fischer synthesis is a method used to:
A.Decrease the number of carbons in a sugar chain
B.Increase the number of carbons in a sugar chain
C.Convert an aldose to a ketose
D.Convert a hexose to a pentose
- 8.
Which reagent is used to convert an aldose to its corresponding epimer at C2?
A.- ; 2. Pyridine, heat; 3.
B.- ; 2. ; 3.
C.- ; 2. ; 3.
D.- Phenylhydrazine; 2.
- 9.
When D-glucose is treated with and followed by hydrolysis with dilute , the product is:
A.2,3,4,6-Tetra-O-methyl-D-glucose
B.2,3,4,5,6-Penta-O-methyl-D-glucose
C.1,2,3,4,6-Penta-O-methyl-D-glucose
D.Methyl -D-glucoside
- 10.
The total number of stereoisomers for the pyranose form of D-glucose (including all possible D and L aldohexoses) is:
A.16
B.32
C.64
D.8
Download the worksheet for Biomolecules - Monosaccharides (Glucose and Fructose) to practice offline. It includes additional chapter-level practice questions.
D-L configuration
SubtopicD-L configuration under Biomolecules for Grade 12 ICSE.
Preview questions (no answers)
- 1.
For a molecule with 'n' chiral centers, how many total stereoisomers are possible?
A.n
B.2n
C.D. - 2.
What is the relationship between the configuration of D-Glucose and D-Mannose?
A.They are enantiomers
B.They are epimers at C-2
C.They are the same molecule
D.One is the L-form of the other
- 3.
In a Fischer projection, the carbon chain is arranged:
A.Horizontally
B.Vertically
C.Diagonally
D.In a ring
- 4.
Which carbon in D-Ribose (an aldopentose) is the chiral center furthest from the aldehyde group?
A.C-2
B.C-3
C.C-4
D.C-5
- 5.
Which of these is a ketohexose that belongs to the -series?
A.-Ribose
B.-Fructose
C.-Sorbose
D.-Erythrose
- 6.
In -glyceraldehyde, the groups attached to the chiral carbon are . Which group is placed at the top in a standard Fischer projection for assignment?
A.B.C.D. - 7.
What is the total number of -aldohexoses?
A.4
B.8
C.16
D.32
- 8.
How many chiral centers are present in -Glyceraldehyde, and what is its IUPAC name including the stereochemical descriptor?
A.1; -2,3-dihydroxypropanal
B.1; -2,3-dihydroxypropanal
C.2; -2,3-dihydroxypropanal
D.1; -1,2-dihydroxypropanal
- 9.
If -Glucose and -Glucose are mixed in equal proportions, what is the specific rotation of the resulting solution?
A.B.C.D. - 10.
In the cyclic Haworth projection of an --glucopyranose, where is the group located?
A.Above the plane of the ring
B.Below the plane of the ring
C.In the same plane as the ring
D.It depends on the anomeric configuration
Download the worksheet for Biomolecules - D-L configuration to practice offline. It includes additional chapter-level practice questions.
Proteins: Amino acids and peptide bonds
SubtopicProteins: Amino acids and peptide bonds under Biomolecules for Grade 12 ICSE.
Preview questions (no answers)
- 1.
Proteins that contain only amino acids upon hydrolysis are called:
A.Conjugated proteins
B.Derived proteins
C.Simple proteins
D.Complex proteins
- 2.
How many water molecules are lost when four amino acids combine to form a tetrapeptide?
A.One
B.Two
C.Three
D.Four
- 3.
The Ninhydrin test is used to detect amino acids. What color is typically produced?
A.Red
B.Blue/Purple
C.Yellow
D.Green
- 4.
Insulin is a hormone that chemically belongs to which class of biomolecules?
A.Carbohydrates
B.Lipids
C.Proteins
D.Nucleic acids
- 5.
In the context of protein chemistry, what is the role of 'Peptidyl transferase'?
A.It breaks peptide bonds during digestion
B.It catalyzes the formation of peptide bonds during translation
C.It denatures proteins in the stomach
D.It helps in the transport of amino acids across membranes
- 6.
Which of the following amino acids is aromatic?
A.Phenylalanine
B.Serine
C.Threonine
D.Valine
- 7.
The term 'zwitterion' comes from the German word for:
A.Neutral
B.Hybrid or Double
C.Balanced
D.Internal salt
- 8.
The values for Glycine are 2.34 and 9.60. At what pH is the concentration of the zwitterion at its maximum?
A.2.34
B.9.60
C.5.97
D.7.00
- 9.
Which of the following amino acids contains a secondary amine within its ring structure?
A.Histidine
B.Proline
C.Tryptophan
D.Phenylalanine
- 10.
A protein solution is treated with concentrated and then with an excess of , resulting in an orange color. This confirms the presence of:
A.Peptide bonds
B.Sulfur-containing amino acids
C.Aromatic amino acids
D.Free amino groups
Download the worksheet for Biomolecules - Proteins: Amino acids and peptide bonds to practice offline. It includes additional chapter-level practice questions.
Structure of proteins (Primary, secondary, tertiary, quaternary)
SubtopicStructure of proteins (Primary, secondary, tertiary, quaternary) under Biomolecules for Grade 12 ICSE.
Preview questions (no answers)
- 1.
Which of these proteins has a quaternary structure consisting of two identical alpha chains and two identical beta chains?
A.Myoglobin
B.Hemoglobin
C.Insulin
D.Ribonuclease
- 2.
The 'pleated' appearance of the -sheet is due to the:
A.Planarity of the peptide bond and the geometry of the -carbon
B.Presence of sulfur atoms
C.High concentration of proline
D.Branching of the main chain
- 3.
Which of the following links amino acids in the primary structure?
A.Glycosidic linkage
B.Phosphodiester linkage
C.Peptide linkage
D.Hydrogen linkage
- 4.
How many amino acid chains compose a single molecule of adult hemoglobin?
A.One
B.Two
C.Three
D.Four
- 5.
Which of the following factors can lead to the denaturation of proteins by disrupting hydrogen bonds and hydrophobic interactions?
A.Addition of heavy metal ions
B.Exposure to concentrated urea solutions
C.Changes in temperature
D.All of the above
- 6.
What type of chemical reaction occurs during the formation of a peptide bond between two amino acids?
A.Addition reaction
B.Condensation reaction
C.Substitution reaction
D.Oxidation-reduction reaction
- 7.
In the -helix, the hydrogen bonds are oriented in which way?
A.Perpendicular to the axis of the helix.
B.Parallel to the axis of the helix.
C.Randomly distributed throughout the structure.
D.Between the side chains only.
- 8.
Which of the following describes the 'Tertiary Structure' correctly?
A.It is solely determined by hydrogen bonds between the backbone and groups.
B.It refers to the long-range folding of the polypeptide chain, bringing distant amino acids into close proximity.
C.It is only present in proteins consisting of more than one polypeptide chain.
D.It is always destroyed by simple dilution of the protein.
- 9.
The peptide bond is nearly planar. In the 'trans' configuration, the dihedral angle () is approximately:
A.B.C.D. - 10.
Which of the following is the most significant force in stabilizing the quaternary structure of proteins like hemoglobin?
A.Peptide bonds between subunits.
B.Non-covalent interactions (hydrophobic, ionic, H-bonds) between the surfaces of different subunits.
C.Permanent covalent linkages between all subunits.
D.Coordinate bonds between the central metal ion and the protein backbone.
Download the worksheet for Biomolecules - Structure of proteins (Primary, secondary, tertiary, quaternary) to practice offline. It includes additional chapter-level practice questions.
Denaturation of proteins
SubtopicDenaturation of proteins under Biomolecules for Grade 12 ICSE.
Preview questions (no answers)
- 1.
What is the consequence of exposing proteins to extreme pH values?
A.The protein becomes more stable
B.The ionic attractions and hydrogen bonds are disrupted
C.The protein turns into a carbohydrate
D.The primary structure is always cleaved
- 2.
A protein in its native state is usually:
A.Randomly coiled
B.Highly organized and folded
C.A straight line of amino acids
D.Insoluble in all solvents
- 3.
The loss of secondary and tertiary structure without breaking peptide bonds is called:
A.Hydrolysis
B.Denaturation
C.Hydrogenation
D.Saponification
- 4.
Which of the following will NOT typically denature a protein?
A.Boiling at
B.Adding strong mineral acids
C.Adding a small amount of table salt at room temperature
D.Adding heavy metal salts
- 5.
Which of the following statements about the denaturation of globular proteins is FALSE?
A.The protein loses its specific biological function
B.The secondary and tertiary structures are disrupted
C.The covalent bonds between amino acid residues are broken
D.The solubility of the protein typically decreases
- 6.
The denaturation of proteins is often accompanied by an increase in the number of detectable:
A.Carboxyl groups
B.Free sulfhydryl groups
C.Peptide linkages
D.Nitrogen atoms
- 7.
Which of the following is a result of the denaturation of the protein 'collagen' in meat during slow cooking?
A.It becomes tougher and more fibrous
B.It converts into gelatin, which is more soluble
C.It turns into fat
D.It breaks down into carbon dioxide
- 8.
In a 'two-state' denaturation model, which of the following is true regarding the population of protein molecules at any given time?
A.Only the native state and the fully unfolded state exist in significant amounts
B.The protein must pass through at least ten different stable intermediate states
C.The protein consists of two different types of amino acid chains
D.The protein can only be denatured by two different methods simultaneously
- 9.
How does the addition of high concentrations of sucrose or glycerol affect the thermal denaturation temperature () of many proteins?
A.It decreases by competing for hydrogen bonds
B.It increases by stabilizing the native state through the mechanism of 'preferential exclusion'
C.It has no measurable effect on the stability of the protein
D.It lowers by causing the reduction of disulfide bonds
- 10.
Which of the following physical properties typically remains largely UNCHANGED when a globular protein undergoes denaturation?
A.The diffusion coefficient
B.The molar mass of the polypeptide chain
C.The sedimentation rate in an ultracentrifuge
D.The intrinsic viscosity of the solution
Download the worksheet for Biomolecules - Denaturation of proteins to practice offline. It includes additional chapter-level practice questions.
Vitamins: Classification and deficiency
SubtopicVitamins: Classification and deficiency under Biomolecules for Grade 12 ICSE.
Preview questions (no answers)
- 1.
Night blindness (inability to see in dim light) is caused by the lack of:
A.Vitamin B12
B.Vitamin A
C.Vitamin K
D.Vitamin C
- 2.
Which vitamin's deficiency causes loss of hair and skin inflammation?
A.Biotin
B.Retinol
C.Thiamine
D.Tocopherol
- 3.
Which vitamin is also known as Ergocalciferol?
A.Vitamin D2
B.Vitamin D3
C.Vitamin A
D.Vitamin E
- 4.
Which vitamin is unique because it cannot be obtained from plant sources and is found only in animal products like meat and curd?
A.Vitamin C
B.Vitamin B12
C.Vitamin B1
D.Vitamin A
- 5.
Vitamins are classified as 'micronutrients' because they are:
A.Needed in large quantities for energy
B.Synthetic compounds not found in nature
C.Required in very small amounts to perform specific biological functions
D.Simple inorganic salts essential for life
- 6.
Pernicious anemia is a severe condition that arises due to the inability to absorb:
A.Vitamin
B.Vitamin
C.Vitamin
D.Folic acid
- 7.
Which vitamin is characterized by the presence of a -lactone ring and two enolic hydroxyl groups?
A.Ascorbic acid
B.Retinol
C.Thiamine
D.Niacin
- 8.
Identify the vitamin that is synthesized by the action of sunlight on 7-dehydrocholesterol in the human skin.
A.Vitamin
B.Vitamin
C.Vitamin
D.Vitamin
- 9.
Which vitamin is known to decrease the plasma level of triglycerides and cholesterol when administered in high pharmacological doses?
A.Niacin
B.Thiamine
C.Riboflavin
D.Biotin
- 10.
The deficiency of which vitamin is associated with a condition known as 'Burning Feet Syndrome'?
A.Pantothenic acid
B.Riboflavin
C.Cobalamin
D.Thiamine
Download the worksheet for Biomolecules - Vitamins: Classification and deficiency to practice offline. It includes additional chapter-level practice questions.
Nucleic Acids: DNA and RNA
SubtopicNucleic Acids: DNA and RNA under Biomolecules for Grade 12 ICSE.
Preview questions (no answers)
- 1.
The base sequence in DNA carries the information for the sequence of:
A.Sugars in a polysaccharide
B.Amino acids in a protein
C.Fatty acids in a lipid
D.Phosphates in a nucleotide
- 2.
The acidity of DNA and RNA is primarily due to the presence of:
A.Nitrogenous bases
B.Hydroxyl groups
C.Phosphate groups
D.Pentose sugars
- 3.
Which of the following bases has a single-ring structure?
A.Adenine
B.Guanine
C.Thymine
D.None of these
- 4.
Nucleic acids are polymers of:
A.Nucleotides
B.Nucleosides
C.Amino acids
D.Pentose sugars
- 5.
The process of transcription involves copying genetic information from a specific DNA strand into a complementary mRNA strand. If the DNA template strand has the sequence and polarity shown in the diagram, which of the following correctly represents the sequence and polarity of the resulting mRNA transcript?
A.B.C.D. - 6.
In the sugar-phosphate backbone of a nucleic acid, the phosphate groups link adjacent pentose sugar molecules together to form a long polymer chain. Based on the structural numbering of the carbon atoms in the pentose sugar shown in the diagram below, which two carbon positions (labeled A-E) are involved in the formation of these phosphodiester linkages?
A.Positions A and E
B.Positions B and C
C.Positions C and E
D.Positions A and B
- 7.
The process by which DNA makes an exact copy of itself is known as:
A.Transcription
B.Translation
C.Replication
D.Mutation
- 8.
What is the specific geometry of the bond in the naturally occurring form of DNA nucleotides?
A.linkage
B.linkage
C.linkage
D.linkage
- 9.
Which of the following factors does NOT contribute to the stabilization of the DNA double helix?
A.Hydrogen bonding between base pairs
B.Base-stacking interactions (hydrophobic and van der Waals forces)
C.Covalent cross-linking between opposite strands
D.Interaction with metal cations like to neutralize phosphate charges
- 10.
A DNA segment has a sequence . How many total hydrogen bonds are holding this sequence to its complementary strand in a double helix?
A.8
B.10
C.12
D.14
Download the worksheet for Biomolecules - Nucleic Acids: DNA and RNA to practice offline. It includes additional chapter-level practice questions.