krit.club logo

Biological Molecules - Structure of DNA

Grade 11A LevelBiology

Review the key concepts, formulae, and examples before starting your quiz.

🔑Concepts

•

DNADNA (Deoxyribonucleic acid) is the molecule that contains the genetic instructions for the development, functioning, growth, and reproduction of all known organisms.

•

The basic unit of DNADNA is a nucleotide, which consists of three parts: a phosphate group, a pentose sugar (deoxyribose), and a nitrogenous base.

•

There are four types of nitrogenous bases in DNADNA: Adenine (AA), Thymine (TT), Cytosine (CC), and Guanine (GG).

•

The DNADNA molecule consists of two strands coiled together to form a double helix.

•

The two strands are held together by hydrogen bonds between complementary base pairs: AA always pairs with TT, and CC always pairs with GG.

•

The 'backbone' of the DNADNA strand is formed by alternating sugar and phosphate groups, linked by strong covalent bonds.

•

The sequence of bases along a DNADNA molecule forms the genetic code, which determines the specific proteins synthesized by the cell.

📐Formulae

[A]=[T][A] = [T]

[C]=[G][C] = [G]

[A]+[G]=[T]+[C]=50%[A] + [G] = [T] + [C] = 50\%

Total percentage=[A]+[T]+[C]+[G]=100%\text{Total percentage} = [A] + [T] + [C] + [G] = 100\%

Phosphate Group=PO43−\text{Phosphate Group} = PO_4^{3-}

💡Examples

Problem 1:

A sample of double-stranded DNADNA is analyzed and found to contain 22%22\% Cytosine (CC). Calculate the percentage of Adenine (AA) present in the sample.

Solution:

28%28\%

Explanation:

According to Chargaff's rules, the amount of Cytosine is equal to Guanine, so [C]=[G]=22%[C] = [G] = 22\%. The total percentage of C+G=22%+22%=44%C + G = 22\% + 22\% = 44\%. The remaining percentage for A+TA + T is 100%−44%=56%100\% - 44\% = 56\%. Since [A]=[T][A] = [T], the percentage of Adenine is 56%÷2=28%56\% \div 2 = 28\%.

Problem 2:

Identify the number of hydrogen bonds formed between a sequence of three base pairs: A−TA-T, G−CG-C, and C−GC-G.

Solution:

88 hydrogen bonds

Explanation:

In DNADNA base pairing, an A−TA-T pair is held together by 22 hydrogen bonds, while a G−CG-C (or C−GC-G) pair is held together by 33 hydrogen bonds. Therefore, the total is 2+3+3=82 + 3 + 3 = 8 bonds.